Cyrmenins, New .Beta.-Methoxyacrylate Inhibitors of the Electron Transport Production, Isolation, Physico-chemical and Biological Properties

Sasse, F.; Leibold, T.; Kunze, B.; Höfle, G.; Reichenbach, H.

The Journal of Antibiotics 56(10): 827-831

2003


DOI: 10.7164/antibiotics.56.827
Accession: 068517049

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Abstract
New antibiotic compounds, named cyrmenins, were isolated from the culture broth of strains of the myxobacteria Cystobacter armeniaca and Archangium gephyra. The compounds belong to the group of beta-methoxyacrylate (MOA) inhibitors and are the first naturally occuring nitrogen-linked MOAs. The cyrmenins show nearly the same antifungal activity as strobilurin A, but are less toxic in a growth inhibition assay with L929 mouse cells. Cyrmenins inhibit NADH oxidation by submitochondrial particles from beef heart. Investigations by difference spectroscopy showed that cyrmenin B1 blocks the electron transport within the cytochrome bc1-segment (complex III) of the respiratory chain.