The irritant properties of dopamine-beta-hydroxylase inhibitors in relation to their effects on L-dopa-induced locomotor activity

Dolphin, A.; Elliott, P.N.; Jenner, P.

Journal of Pharmacy and Pharmacology 28(10): 782-785

1976


ISSN/ISBN: 0022-3573
PMID: 10378
DOI: 10.1111/j.2042-7158.1976.tb04051.x
Accession: 068517884

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Abstract
Inhibitors of dopamine-.beta.-hydroxylase (DBH) (EC 1.14.2.1) are extensively employed in neuropharmacology for their ability to specifically block the synthesis of noradrenaline , caused by reserpine. Only FLA-63 and U10,157 were effective in attenuating L-dopa-induced locomotor activity in both normal and reserpinized mice, at doses which were previously shown to inhibit noradrenaline synthesis from L-dopa.