Inhibitory effect of membrane active compounds on the uptake of 14C-alpha-aminoisobutyric acid (AIB) in cultured chick embryo liver cells

Schoenfeld, N.; Epstein, O.; Atsmon, A.

Life Sciences 21(3): 329-334


ISSN/ISBN: 0024-3205
PMID: 19669
DOI: 10.1016/0024-3205(77)90513-6
Accession: 068518158

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High concentrations of beta-adrenoceptor blocking drugs with membrane active properties and of the membrane active compounds quinidine and lidocaine inhibit the uptake of ∝-aminoisobutyric acid by chick embryo liver cells in culture. Beta-adrenoceptor blockers without membrane active properties were without effect. These results are in accordance with previous findings which showed partial inhibition of incorporation of amino acids into proteins caused by membrane active drugs in this system.