Treatment of peptic ulcer in the Zollinger-Ellison syndrome with histamine H2-receptor antagonists

Hausamen, T.U.; Fritsch, W.P.; Scholten, T.; Jungblut, R.; Strohmeyer, G.

Deutsche Medizinische Wochenschrift 102(47): 1709-1712


ISSN/ISBN: 0012-0472
PMID: 21785
DOI: 10.1055/s-0028-1105561
Accession: 068518247

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Histamine H2-receptor antagonists metiamide and cimetidine were used in the treatment of severe peptic ulceration in Zollinger-Ellison syndrome. The ulcerations were completely healed in all four patients after treatment lasting from six weeks to four-and-a-half-months. Two patients developed recurrent ulcer after the treatment had stopped, but responded to a second course. One patient developed hepatitis B during cimetidine treatment and it is possible that the course of the hepatitis was unfavourable affected by cimetidine. But no other side effects were noted nor was there a significant change in basal serum-gastrin concentration or an increase in H+ secretion. Total gastrectomy remains the treatment of choice in Zollinger-Ellison syndrome, but cimetidine should be considered if the patient refuses operation or operation is not feasible because of a poor general state.