Effect of 5,6-dihydroxytryptamine on the head twitches induced by 5-HTP, 5-HT, mescaline and fludiazepam in mice

Nakamura, M.; Fukushima, H.

Journal of Pharmacy and Pharmacology 30(1): 56-58

1978


ISSN/ISBN: 0022-3573
PMID: 22729
DOI: 10.1111/j.2042-7158.1978.tb13156.x
Accession: 068518278

Download citation:  
Text
  |  
BibTeX
  |  
RIS

Article/Abstract emailed within 0-6 h
Payments are secure & encrypted
Powered by Stripe
Powered by PayPal

Abstract
The effect of the degeneration of serotoninergic neuron terminals, as a result of treatment with 5,6-DHT [5,6-dihydroxytryptamine], on head twitches induced in mice by 5-HTP [5-hydroxytryptophan], 5-HT [5-hydroxytryptamine], mescaline and fludiazepam (ID-540), a new benzodiazepine possessing anticonvulsant, taming, sedative and muscle-relaxant properties in animals was reported. Although the head twitches induced by 5-HTP, 5-HT, mescaline and fludiazepam are thought to be caused by the increased activity of serotoninergic neurons, their mechanism is not the same; 5-HTP and 5-HT induce twitches by increasing the free concentration of 5-HT at its receptor sites, mescaline by its direct action on 5-HT receptors, and fludiazepam by the activation of 5-HT receptors.