Increased binding of [3H]apomorphine in caudate membranes after dopamine pretreatment in vitro

McManus, C.; Hartley, E.J.; Seeman, P.

Journal of Pharmacy and Pharmacology 30(7): 444-447


ISSN/ISBN: 0022-3573
PMID: 27612
DOI: 10.1111/j.2042-7158.1978.tb13283.x
Accession: 068518415

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Although long-term exposure of .beta.-adrenergic catecholamines generally results in tachyphylaxis or desensitization, long-term administration of dopamine-mimetic drugs to animals sometimes produces behavioral facilitation. To investigate 1 possible molecular mechanism of this facilitation or sensitization induced by dopamine-mimetic drugs, the effects of prolonged exposure (in vitro) of dopamine were studied on the dopamine/neuroleptic receptors in the caudate nucleus of the calf. The specific binding of apomorphine binding may be reasonably selective for dopamine receptors. However, the fact that both noradrenaline and dopamine were almost equipotent in producing this increase indicates that the effect was not extremely chemically specific.