FSH: III. Evidence for a possible prepubertal regulation of its secretion by the seminiferous tubules in cryptorchid boys

Sizonenko, P.C.; Schindler, A.M.; Roland, W.; Paunier, L.; Cuendet, A.

Journal of Clinical Endocrinology and Metabolism 46(2): 301-308


ISSN/ISBN: 0021-972X
PMID: 35550
DOI: 10.1210/jcem-46-2-301
Accession: 068518618

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Two groups of prepubertal unilateral cryptorchid boys, 4 yr 2 mo. to 12 yr of age, underwent stimulation tests with 1 .mu.g (n = 10) or 25 .mu.g (n = 8) of LHRH responses to 1 and 25 .mu.g of LHRH similar to those of the prepubertal control groups. The numbers of spermatogonia were low (means .+-. SE of 12 .+-. 6 to 25 .+-. 12) on the cryptorchid side, and in the normal range (greater than 50 per 50 tubular transverse sections) on the normal side. Both groups of bilateral cryptorchid patients had very low counts of spermatogonia on both testicular sides (means of 7 .+-. 4 to 14 .+-. 8). Their FSH responses to LHRH at both dosages were significantly increased when compared with the normal prepubertal responses and similar to those of the pubertal control groups. LH responses to LHRH were identical for both cryptorchid groups and prepubertal control groups. The negative feedback mechanism between FSH secretion and the seminiferous tubules present in the adult male may be also operative in the prepubertal boy.