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Convulsive properties of lindane, lindane metabolites, and the lindane isomer alpha-hexachlorocyclohexane: effects on the convulsive threshold for pentylenetetrazol and the brain content of gamma-aminobutyric acid (GABA) in the mouse



Convulsive properties of lindane, lindane metabolites, and the lindane isomer alpha-hexachlorocyclohexane: effects on the convulsive threshold for pentylenetetrazol and the brain content of gamma-aminobutyric acid (GABA) in the mouse



Toxicology and Applied Pharmacology 46(1): 101-108



The threshold for pentylenetetrazol-induced convulsions in the mouse is affected by lindane in 2 opposite ways. Following the administration of a single dose of lindane, the threshold first decreases and then, after 2 days, increases above the normal level. None of the tested metabolites of lindane altered the convulsive threshold. When lindane elevates the convulsive threshold it also elevates the content of GABA in the brain. The lindane isomer .alpha.-hexachlorocyclohexane elevates both convulsive threshold and the GABA content. The smallest single oral dose of lindane lowering the convulsive threshold for pentylenetetrazol in the mouse, 3 h after administration, corresponds to a lindane concentration of 56 ppb in whole blood.

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Accession: 068519963

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PMID: 83029

DOI: 10.1016/0041-008x(78)90140-0


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