Hypothesis: nonspecific polyclonal activation of memory B cells by antigen as a mechanism for the preservation of long term immunologic anamnesis

Moticka, E.J.; Streilein, J.W.

Cellular Immunology 41(2): 406-413


ISSN/ISBN: 0008-8749
PMID: 83204
DOI: 10.1016/0008-8749(78)90237-x
Accession: 068519967

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Antigen stimulation, while eliciting the production of specific antibodies, also induces a nonspecific polyclonal hyperimmunoglobulinemia which includes antibodies directed at previously experienced antigens. These antibodies may play an important role in the physiologic maintenance of long term immunologic memory by providing a continuing source of newly synthesized molecules which recapitulate the individual's immunologic history. The immunoglobulin produced during these responses becomes associated with local macrophages through the Fc receptors. This interaction arms these cells, thereby enhancing the likelihood of increasingly avid uptake of subsequent antigenic challenges. By greatly promoting the presentation of antigens within lymph node and spleen to long lived, recirculating T multiple myeloma.