The influence of secretin, glucagon and other peptides, of amino acids, prostaglandin endoperoxide analogues and diazepam on the level of adenosine 3',5'-cyclic monophosphate in neuroblastoma x glioma hybrid cells

Propst, F.; Moroder, L.; Wünsch, E.; Hamprecht, B.

Journal of Neurochemistry 32(5): 1495-1500


ISSN/ISBN: 0022-3042
PMID: 86600
DOI: 10.1111/j.1471-4159.1979.tb11090.x
Accession: 068520143

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Neuroblastoma .times. glioma hybrid AMP in the hybrid cells. Two prostaglandin endoperoxide analogs exhibited a weak stimulatory action, if applied in at least micromolar concentrations. At nanomolar concentrations, only the gastrointestinal hormones secretin and glucagon stimulated the formation of cAMP, as detected in the presence of a phosphodiesterase inhibitor. The effect of secretin but not that of glucagon is antagonized by secretin-(5-27), suggesting that secretin and glucagon act on the cells via different receptors. These results appear to be noteworthy since an effect of secretin or glucagon on a cell with neuronal characteristics has not yet been described and many peptide hormones have been detected both in the gastrointestinal tract and the nervous system.