A 14q+ chromosome in a B-cell acute lymphocytic leukemia and in a luekemic non-endemic Burkitt lymphoma

Slater, R.M.; Philip, P.; Badsberg, E.; Behrendt, H.; Hansen, N.E.; van Heerde, P.

International Journal of Cancer 23(5): 639-647


ISSN/ISBN: 0020-7136
PMID: 88421
DOI: 10.1002/ijc.2910230509
Accession: 068520294

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Chromosome analysis using banding staining techniques was carried out on cells from a B[bone marrow-derived]-cell acute lymphocytic leukemia (ALL) of the Burkitt type and a case of non-endemic Burkitt lymphoma presenting as ALL. In both patients a marker chromosome 14q+ was found which was morphologically identical to those reported for endemic and nonendemic Burkitt lymphoma and a few other B-cell malignancies. The origin of the translocated segment could not be identified in either case. Both patients had a 13q+ chromosome with a breakpoint in the 13q3 region but involving different material of unknown origin. Other marker chromosomes in the B-cell ALL included rearrangements of chromosome arms 1q and 6q. Serial studies showed that cells with a partial duplication of the long arm of chromosome No. 1, in addition to the 14q+ chromosome, were important in the karyotype evolution of the malignant cell population. In this patient the 14q+ chromosome had a brightly fluorescing satellite region, indicating the probable monoclonal development of the leukemic cell population. The B-cell type of ALL apparently is characterized by a 14q+ chromosome. The pathological and cytogenetic similarities between certain types of B-cell ALL and Burkitt lymphoma suggest that they may be different manifestations of the same disorder.