Genetic control of effector cell characteristics: con A-induced suppressor cells carry H-2 i region encoded determinants

Primi, D.; Hammarström, L.; Möller, E.; Smith, C.I.

Cellular Immunology 47(1): 143-152


ISSN/ISBN: 0008-8749
PMID: 92365
DOI: 10.1016/0008-8749(79)90322-8
Accession: 068520547

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Activation of splenic lymphocytes with Concanavalin A [Con A] leads to the formation of suppressor cells capable of interfering with the activity of several polyclonal B[bone marrow-derived]-cell-activating substances. These suppressor cells (or their products) most probably act directly on B cells. Suppressor cells were recovered from the effluent cell population of nylon wool columns but were absent from the spleens of athymic nude mice. They were absent from the thymus of normal and cortisone-treated mice. Cortisone treatment did not abolish the formation Con-A-induced suppressor cells in the spleen. Treatment of activated suppressor cells with antisera specific for distinct products of the H-21 I region revealed that they carried I-J cell surface antigens. The suppressor cells in this test system, have a direct effect on B cells (unlike other Con A-induced suppressor cell populations) and have antienic characteristics similar to those previously described for I-J carrying suppressor cells.