Relationship between receptor occupancy and stimulation of adenosin-3',5'-monophosphate (cAMP) and progesterone production in isolated rat granulosa cells

Doerr, P.

Journal of Steroid Biochemistry 11(3): 1197-1200


ISSN/ISBN: 0022-4731
PMID: 92614
DOI: 10.1016/0022-4731(79)90183-3
Accession: 068520553

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In granulosa cells isolated from preovulatory follicles of PMSG the entire range of the progesterone response curve shifted to lower hCG concentrations indicating a sufficient cAMP level within an intracellular compartment for mediating steroidogenic response. Granulosa cells obviously differ from rat Leydig cells where maximum steroidogenic response is achieved when only 1% of the LH receptors are occupied.