Are VH framework antigenic determinants expressed on both rabbit B and T lymphocytes?

Wilder, R.L.; Yuen, C.C.; Scher, I.; Mage, R.G.

European Journal of Immunology 9(10): 777-783


ISSN/ISBN: 0014-2980
PMID: 93052
DOI: 10.1002/eji.1830091007
Accession: 068520572

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The extent to which VH cell origin) were readily demonstrated by immunoprecipitation. No evidence for a population of cells or a class of molecule(s) bearing VH in the absence of L or H chain constant region determinants was obtained. Although these studies do not support the concept of similar VH framework determinants on T and B cell receptors, they do not exclude a much more limited sharing of determinants or a very minor T cell subpopulation which expresses VH framework that would not be detectable by the methods used in these studies.