The PAS reactivity of the lymph-node blast cells in non-Hodgkin's malignant lymphomas

Riccardi, A.

Haematologica 63(5): 521-530


ISSN/ISBN: 0390-6078
PMID: 107071
Accession: 068520842

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The behavior of lymph node blast cells to the periodic acid-Schiff (PAS) reaction was studied in lymph node imprints from 31 human cases of non-Hodgkin's lymphomas, histologically classified according to Rappaport's, Lukes' and Collins' classifications. Variable degrees of positivity, in the form of granular cytoplasmatic inclusions, were observed in 17 (55%) cases. The pattern of reactivity was similar in lymphocytic and histiocytic lymphomas of the Rappaport classification. Among the Lukes and Collins' subtypes, the small cleaved follicular center cell lymphomas were unreactive in all but 1 case. The presence of 40% or more small cleaved cells among the blast cell population was frequently associated with PAS negativity in the other histologic subtypes. PAS positivity was abolished by salivery digestion indicating the glycogenic composition of the stainable material. This finding is in contrast with the observations made by Lennert on histologic preparations. PAS reactivity of non-Hodgkin's lymphoma cells may not be due to glycoprotein (immunoglobulins).