The developmental and aging processes of Schlemm's canals

Katsume, Y.; Yoshizuka, M.

Kurume Medical Journal 26(2): 175-184


ISSN/ISBN: 0023-5679
PMID: 116069
Accession: 068521061

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Schlemm's canal (sinus venous sclerae) of human fetuses and postnatal monkeys (Macaca fuscata) were observed by light microscopy and EM. Between the 21st-24th wk of fetus gestation many branches of Schlemm's vascular plexus at the sclerocorneal junction (an immature form of Schlemm's canal) were connected by young fibroblasts invading from the surrounding connective tissue. Apparently, the main pathway of aqueous humor transport across the endothelium of the canal is converted from intercellular into intracellular (transported by vacuoles and pores) during these stages. In the postnatal monkeys, large vacuoles were observed in the differentiating endothelium at the inner wall of the canal. EM showed these vacuoles were formed by a successive fusion of adjacent pinocytotic vesicles in the endothelial cells and are important for aqueous humor transport.