Effect of in vitro passages on biological properties of the attenuated strains of measles virus. I. Replication and antigenic properties

Lityńska, J.

Medycyna Doswiadczalna i Mikrobiologia 31(2): 111-120


ISSN/ISBN: 0025-8601
PMID: 116097
Accession: 068521062

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Measles virus strains L-16, Enders and Edmonston were adapted to primary culture of Japanese quail embryo fibroblasts (FZP). FZP is a system which permits virus replication without respect to which systems the strains were adapted previously. Infectious titers determined in FZP differed from those in other cell systems (e.g., HeLa ). FZP infected with measles virus produced interferon. Among the 3 strains tested, Edmonston appeared the weakest interferon inducer. Strains adapted to FZP showed differences in HA activity. Strains L-16 and Edmonston agglutinated monkey erythrocytes in the isotonic saline. Enders strain antigen adsorbed on monkey erythrocytes only in hypertonic (NH4)2SO4 solution and eluted in the isotonic saline.