Granulocyte progenitor cells in peripheral blood and leucocyte CSA in patients with neutrophilic leucocytosis not due to haematological disease. a clinical study

Morra, L.; Ponassi, A.; Gigli, G.; Molinari, A.; Sacchetti, C.

Haematologica 64(5): 561-569

1979


ISSN/ISBN: 0390-6078
PMID: 116916
Accession: 068521077

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Abstract
The incidence of circulating colony forming cells (CFU-C) and the ability of peripheral leukocytes to stimulate the colony formation (CSA) were studied through a double layer agar culture system in 18 patients with neutrophilic leukocytosis not due to hematological disease and compared to the values obtained in 69 normal subjects. Mean CFU-C incidence and mean leukocyte CSA of the whole group of patients were significantly higher than normal, but considerable variation was observed among singular patients. An attempt was made to refer the combined pattern of CFU-C incidence and leukocyte CSA of any singular patient to the different clinical conditions (infectious disease, neoplasm, ulcerative colitis, regional enteritis, collagen disease), the different stages in the course of the leukocytosis and the presence of concomitant conditions such as anemia, polycythemia, splenectomy, prednisone treatment, dyslipidemia, that may influence this study. The combined evaluation of blood CFU-C and leukocyte CSA was a useful tool to investigate pathogenetic mechanisms of neutrophilic luekocytosis.