Specificity and suppressor function of human T cells responsive to autologous non-T cells

Sakane, T.; Green, I.

Journal of Immunology 123(2): 584-589


ISSN/ISBN: 0022-1767
PMID: 156761
Accession: 068522721

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Human T A-induced suppressor cells, the T cell population responsive in the autologous MLR might be particularly enriched in cells capable of developing suppressor capacity. A BUdR and light treatment was used to remove T cells responsive to autologous or allogeneic non-T cells. The remaining cells were then activated by Con A and their subsequent suppressor activity was measured. Removal of T cells proliferating in response to autologous non-T cells produced significantly greater failure of suppressor cell development than did the removal of T cells responsive to allogeneic non-T cells. T cells capable of responding to autologous non-T cells are particularly enriched in cells capable of becoming suppressor cells.