Tryptophan oxygenase in the liver and Albert hepatoma in mice

Salwa, J.

Archivum Immunologiae et Therapiae Experimentalis 23(5): 701-713


ISSN/ISBN: 0004-069X
PMID: 175761
Accession: 068523083

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Tryptophan oxygenase activity (TO) [EC-] was studied in Albert mouse hepatoma, in the liver of mice bearing the tumor and in the liver of healthy animals. The influence of typtophan, hydrocortisone and cyclophosphamide in vivo, and hematin in vitro on TO activity was investigated. TO was determined in animals after adrenalectomy and partial hepatectomy. TO in Albert hepatoma was present mainly in the form of active holoenzyme, substrate induction of which was of the same order as in the livers of normal animals, while hormonal induction was impaired. Partial hepatectomy apparently had no influence on TO activity.