Regulation of immune responses. II. the cellular basis of cyclic AMP effects on humoral immunity

Teh, H.S.; Paetkau, V.

Cellular Immunology 24(2): 220-229


ISSN/ISBN: 0008-8749
PMID: 181147
DOI: 10.1016/0008-8749(76)90207-0
Accession: 068523196

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DbcAMP helper cells, and it inhibits the function of macrophages. The stimulatory activity of DbcAMP to anti-SRBC and anti-POL responses is through inhibition of a .theta.-bearing regulator (or suppressor) cell. Removal of T cells by anti-.theta. treatment has the same effect on the anti-POL response as treatment with DbcAMP. In the absence of T cells, the enhanced anti-POL response was insensitive of DbcAMP treatment. The number of anti-SRBC AFC formed is probably regulated by the ratio of T helper to T regulator cells.