Genetic control of RAV-O production in chickens

Crittenden, L.B.; Motta, J.V.; Smith, E.J.

Virology 76(1): 90-97

1977


ISSN/ISBN: 0042-6822
PMID: 189500
DOI: 10.1016/0042-6822(77)90285-9
Accession: 068523409

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Abstract
Progeny of backcross and 2nd backcross matings of a RAV-0-producing line [Rous associated virus type-0] to a line producing RAV-0 at a low frequency were assayed for RAV-0 production. The producing line may be homozygous for an autosomal-dominant gene controlling RAV-0 production. A 2nd line was crossed and backcrossed to the low-producing line, and the frequency of RAV-0 production by the progeny also agreed with the single-dominant gene hypothesis. However, when the 2 producing lines were crossed and their F1 progeny were mated to the low-producing line, 80% of the progeny produced RAV-0. This deviation from the expected 100%, assuming that the 2 lines were homozygous at the same locus, suggested that the RAV-0-controlling genes were at different loci in the 2 lines. An alternative hypothesis, which supposes that the negative tester line carries a defective provirus which is complemented by recessive alleles from either positive line, also is suggested.