Genital herpes in Honduras and its relation to carcinoma of the cervix

Figueroa, M.; Zambrana, A.

Revista Latinoamericana de Microbiologia 18(2): 111-116


ISSN/ISBN: 0187-4640
PMID: 190662
Accession: 068523433

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The prevalence of genital herpes virus (HSV-type 2) infections in Honduras was studied by isolation of the virus and the measurement of neutralizing antibodies in people of particular epidemiologic interest. The findings were analyzed in relation to the possible viral etiology of carcinoma of the cervix. HSV was isolated in 7 of 200 vaginal secretions (3.5%) from pregnant women and in 3 of 30 samples (7.7%) from women with invasive carcinoma of the cervix. In the smegma, HSV was isolated with a frequency of 1.4% of 70 normal men and 6.4% of 203 men attending a venereal disease clinic. Antibodies against HSV are acquired early in life: by the 5th yr 76.6% of 222 children tested had neutralizing antibodies against HSV. In the first 4 yr of life the frequency of antibodies was higher in girls and in boys. An antibody II/I index .gtoreq. 85, indicative of infection with HSV-type 2, was found in the following frequency: children 5%, high school girls 23%, pregnant women 46%, prostitutes 79%, women with cancer of the cervix 68%. Apparently genital HSV is venerally transmitted and is found frequently in association with carcinoma of the cervix.