Ca ionophore-stimulated ion secretion in rabbit ileal mucosa: relation to actions of cyclic 3',5'-AMP and carbamylcholine

Bolton, J.E.; Field, M.

Journal of Membrane Biology 35(2): 159-173

1977


ISSN/ISBN: 0022-2631
PMID: 196088
DOI: 10.1007/bf01869947
Accession: 068523653

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Abstract
Addition of the Ca ionophore, A23187 , secretagogues known to have no effect on intracellular cAMP level in intestinal mucosa, were dependent on extracellular Ca to produce their full electrical response (although, in the case of carbamylcholine at least, Sr can substitute for Ca). The secretagogues vasoactive intestinal peptide and prostaglandin E1, which raise cAMP concentration in intestinal mucosa, do not appear to require external Ca. Ca may be an intracellular mediator of intestinal ion and water secretion and some intestinal secretagogues may act as Ca ionophores.