Short communication on the molecular structure of the opiate receptor

Smythies, J.R.

Psychoneuroendocrinology 2(1): 71-72


ISSN/ISBN: 0306-4530
PMID: 198835
DOI: 10.1016/0306-4530(77)90034-8
Accession: 068523755

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An hypothesis for the molecular structure of the opiate receptor based on 2 opposed parallel Kusnetsov-Ghokov grids was discussed. A study of the molecular structure of a wide variety of opiate agonists and antagonists suggested that the complementary opiate receptor consists of a cup with a marked 3-dimensional topology. This cup in the model was constructed of 4 pentapeptide segments of protein chain aligned as 2 .beta.-pleated (anti-parallel) sheets.