Short communications the presynaptic neuromuscular blocking action of taipoxin. A comparison with beta-bungarotoxin and crotoxin

Chang, C.C.; Lee, J.D.; Eaker, D.; Fohlman, J.

Toxicon Official Journal of the International Society on Toxinology 15(6): 571-576


ISSN/ISBN: 0041-0101
PMID: 198917
DOI: 10.1016/0041-0101(77)90108-8
Accession: 068523759

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The presynaptic effect of taipoxin was compared with that of .beta.-bungarotoxin and crotoxin. No qualitative difference exists among the effects of these toxins but that their relative potencies are different in different species of animals. .beta.-Bungarotoxin and crotoxin were purified from the venoms of Bungarus multicinctus and Crotalus durissus terrificus, respectively, by chromatography. Taipoxin was isolated from the venom of Oxyuranus scutellatus scutellatus by gel filtration followed by column zone electrophoresis on cellulose powder. The LD50 in mice were 0.002 .mu.g/g (i.v.) for taipoxin, 0.02 .mu.g (i.p.) for .beta.-bungarotoxin and 0.05 .mu.g/g (i.p.) for crotoxin. The times needed to block neuromuscular transmission in the isolated rat and mouse phrenic nerve-diaphragms and in the chick biventer cervicis muscle are compared. Taipoxin was 3 times more potent than .beta.-bungarotoxin and 5 times more potent than crotoxin in blocking the mouse diaphragm preparation, but was 30 and 100 times less potent, respectively, than crotoxin and .beta.-bungarotoxin in the chick muscle.