The harmala alkaloids: evidence for their complex inhibition of the K+-acyl phosphatase reaction of membranes

Simonson, L.P.; Charnock, J.S.

Molecular Pharmacology 15(3): 620-626

1979


ISSN/ISBN: 0026-895X
PMID: 226861
Accession: 068524804

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Abstract
Although the harmala alkaloids were originally reported to be specific inhibitors of the Na+-activation site of (Na+ + K+)-ATPase and for K+-activation of the system in the presence of harmaline suggests that activation and inhibition do not occur at the same site. The harmala alkaloids are hallucinogenic compounds which induce disturbances in behavior and perception.