The role of glucocorticoids in the regulation of glucose-6-phosphatase activity in fetal rat liver

Mizushima, Y.; Ishikawa, M.

Biochemical Pharmacology 28(15): 2279-2283


ISSN/ISBN: 0006-2952
PMID: 227405
DOI: 10.1016/0006-2952(79)90690-7
Accession: 068524821

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In organ culture of fetal rat liver explants, glucagon (5 .times. 10-5 M) or dibutyryl cyclic AMP-mediated increase in the enzyme activity and a more intense suppression by the latter of the action of endogenous cAMP. Glucocorticoids may play an important role in the regulation of glucose-6-phosphatase activity by modulating the action of cAMP in fetal rat liver during late pregnancy.