Status of plasma blood clotting factors during different stages of erythromyelosis in rats and the effect of hexaphosphamide on the indices studied

Stepanian, M.A.; Chilingarian, A.G.; Muradian, L.B.

Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny 18(2): 24-28


ISSN/ISBN: 0514-7484
PMID: 278414
Accession: 068525389

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Studies on rats with experimental erythremic myelosis revealed extensive disturbances in all phases of blood coagulation. Changes in the blood coagulation factors varied as a function of the stage of the disease. An increase in the blood coagulation properties together with a reduction in the prothrombin and proaccelerin concentrations were observed in the 1st stage. A noticeable decrease in blood coagulation was observed in the terminal stage, together with a sharp reduction in procoagulant concentrations and an intensified anticoagulant activity. Repeated (6 times) injections of hexaphosphamide, a cytostatic, in the terminal stage of the disease resulted in complete regression of the tumor and in a significant improvement in the blood coagulation activity.