New reciprocal-type marker translocations of T (7, 14) 2 IEM and T (7, 14, 15) 3 IEM in Mus musculus laboratory mice

Baranov, V.S.

Genetika 15(9): 1651-1660

1979


ISSN/ISBN: 0016-6758
PMID: 290546
Accession: 068525494

Download citation:  
Text
  |  
BibTeX
  |  
RIS

Article/Abstract emailed within 1 workday
Payments are secure & encrypted
Powered by Stripe
Powered by PayPal

Abstract
Cytogenetic analysis of mitotic and meiotic chromosomes in mice with new spontaneous reciprocal translocations T(7,14)2 Iem and T(7,14,15)3 Iem was carried out. The T2 Iem translocation resulted from unequal exchange between chromosomes 7 and 14 so that almost all the chromosome 14, except its small centromeric region, is moved to the distal end of the chromosome 7. Differential staining and chromosome measurements revealed the location of break points in Giemsa-negative regions of both chromosomes involved in rearrangement, namely 7 F3-F4 and 14 A2-A3. The T3 Iem translocation was found in the progeny of mice heterozygous for both T(7,14)2 Iem and T(14,15)6Ca translocations. This rearrangement is a result of tandem linkage of 3 different autosomes, 7, 14 and 15, with the chromosome 7 at the centromeric end, 14 in the middle and 15 at the distal part of major translocation product. Two other translocation products are centromeric regions of chromosomes 14 and 15. All rearranged chromosomes in both translocations are easily distinguished in mitotic and meiotic metaphase plates and can be a reliable cell markers. The origin of translocations and some perspectives of their using in experimental cytogenetic and embryologic investigations are discussed.