Regulation of the immune response in autoimmune NZB/NZW F1 mice. I. the spontaneous generation of splenic suppressor cells

Roder, J.C.; Bell, D.A.; Singhal, S.K.

Cellular Immunology 29(2): 272-284


ISSN/ISBN: 0008-8749
PMID: 301058
DOI: 10.1016/0008-8749(77)90322-7
Accession: 068525616

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The spleens of aging NZB .times. NZW F1 (B/W) mice, but not age-matched normal strain mice, contained small radioresistant, nonphagocytic mononuclear cells capable of suppressing early events during the induction of the anti-SRBC response in vivo and the level of suppressive activity in vitro for individual mice. This suppressor cell may lead to the age dependent decline in the immune response to foreign erythrocyte antigens in B/W mice. The increasing suppressor activity with age may be associated with the autoimmune response in these mice.