Dual biological function of a T-cell-derived murine immunoenhancing factor

Rubin, A.S.; Carpenter, C.R.

Cellular Immunology 34(1): 104-111


ISSN/ISBN: 0008-8749
PMID: 303152
DOI: 10.1016/0008-8749(77)90233-7
Accession: 068525704

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Murine enhancing factor (MEF), derived from the culture fluid of mixtures of histoincompatible spleen cells, was found to have 2 apparently different, but perhaps closely related, biological activities. MEF can functionally replace T thymidine by cultured bone marrow cells. Morphologically, the cells comprising the CFU were macrophage-like in appearance. MEF may function as a differentiation signal for the maturation of antigen-activated B lymphocytes into immunoglobulin-secreting cells, and for the modulation of hematopoietic or granulopoietic macrophage stem cells into mature, functional macrophages.