Suppressor cells in contact sensitivity. Effect on T cells helping antibody production to picryl chloride

Thomas, W.R.; Watkins, M.; Asherson, G.L.

Cellular Immunology 34(2): 319-325


ISSN/ISBN: 0008-8749
PMID: 303941
DOI: 10.1016/0008-8749(77)90254-4
Accession: 068525734

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T plaque-forming cell response of mice pained with picryl chloride. They did not directly inhibit the activity of the helper cells but did inhibit the ability of mice to generate helper cells after skin painting. The suppressor cells were T cells as tested by passage through nylon wool columns and sensitivity to anti-.theta. serum. Viable syngeneic cells were required for suppression and their effect was specific. The suppressor cells could not be generated in adult thymectomized mice but could be produced in mice treated with high doses (200 mg/kg) of cyclophosphamide. These properties are distinct from those of suppressor T cells produced following immunization with picryl chloride but are the same as those of other suppressor cells induced by PSA which inhibit contact hypersensitivity.