Malignant histiocytosis

Huhn, D.; Meister, P.; Thiel, E.; Bartl, R.; Theml, H.

Deutsche Medizinische Wochenschrift 103(2): 55-61


ISSN/ISBN: 0012-0472
PMID: 304801
DOI: 10.1055/s-0028-1104381
Accession: 068525756

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According to observations in six patients and published reports, malignant histiocytosis is characterized by premature multifocal proliferation of atypical histiocytes, especially in lymph-nodes, spleen, liver, bone marrow, and lung. The diagnosis can be confirmed by electron-microscopy, and enzyme as well as immunocytochemical tests. Fever, anaemia, leukopenia (with absolute reduction in T-lymphocytes), and jaundice are frequent. Immunoglobulins are normal or polyclonally increased. Malignant histiocytosis is more like monocyte leukaemia and histiocytosis X than neoplasms of the lymphatic system.