Effect of adult T-cell leukemia cells on pokeweed mitogen-induced normal B-cell differentiation

Uchiyama, T.; Sagawa, K.; Takatsuki, K.; Uchino, H.

Clinical Immunology and Immunopathology 10(1): 24-34


ISSN/ISBN: 0090-1229
PMID: 306907
DOI: 10.1016/0090-1229(78)90005-3
Accession: 068525821

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Leukemic T [thymus-derived] cells from Japanese patients with adult T cell leukemia were studied for their effects on pokeweed mitogen-induced peripheral blood lymphocyte differentiation into immunoglobulin-producing cells. Allogeneic peripheral blood lymphocytes, normal T cells, nonlymphoid leukemia cells, lymphoid leukemia cells other than adult T cell leukemia cells and long-term T cell lines did not suppress normal B cell differentiation in coculture experiments. Leukemic T cells from 3 of 6 patients with adult T cell leukemia showed a marked suppressive effect. Supernatant fluids obtained from a short-term (48 h) culture of leukemic T cells from 1 of these 3 patients also showed a marked suppressive effect on B [bone marrow-derived] cell differentiation at a final dilution of 1/5 or less when added at the beginning of the culture (on day 0) or on day 1. Supernatant fluids did not manifest suppressor activity when added on day 3 or later, or when heated at 56.degree. C for 30 min before addition.