Immunological properties of Fc receptor on lymphocytes. 4. Fc receptor of Con a induced suppressor and helper T cells

Yodoi, J.; Takabayashi, A.; Masuda, T.

Cellular Immunology 39(2): 225-237


ISSN/ISBN: 0008-8749
PMID: 308852
DOI: 10.1016/0008-8749(78)90099-0
Accession: 068525896

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When spleen cells or thymocytes of BALB/c mice were cultured with 2 .mu.g/ml of concanavalin A (Con A) for 3 days, helper and suppressor cells for the in vitro plaque forming cell (PFC) response to soluble and particulate antigens (DNP-Asc cells was observed from days 3-5 only in the former cell population. Suppressor cells were also induced preferentially from the former subset. Depletion of the neogeneic FcR+ cells from the Con A-induced suppressor cell population resulted in the loss of the suppressive effect. This suppressor activity of FcR+ cells is proved in priamry and secondary responses to particulate and soluble antigens.