Post-capillary venules of the lymphatic tissues in mice with special reference to the depletion of T-lymphocyte population

Syrjänen, K.J.

Experimental and Molecular Pathology 29(3): 291-302

1978


ISSN/ISBN: 0014-4800
PMID: 309830
DOI: 10.1016/0014-4800(78)90072-2
Accession: 068525940

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Abstract
The morphology of the post-capillary venules in the lymph nodes, thymus and Peyer's patches of DBA/2 mice was assessed light microscopically with special reference to the depletion of T[thymus-derived]-lymphocyte population in these animals. As an immunosuppressive treatment the heterologous anti-thymus .gamma.-globulin and anti-theta .gamma.-globulin was used. Three classes of post-capillary venules were differentiated on the basis of the height of the endothelium of these vessels. For each of the organs studied the post-capillary venule score (PCV-S) was counted, and it was these scores that were compared in the 4 series studied. The highest scores were encountered in the lymph nodes of the control, non-treated animals. The treatment with normal rabbit .gamma.-globulin did not affect these high scores, but statistically significantly lower scores were obtained in animals treated with anti-thymus- or anti-theta globulins. The scores of the Peyer's patches behaved analogous to those of the lymph nodes, but those of the thymuses remained unchanged despite the immunosuppressive treatment. The post-capillary venules of the lymph nodes and Peyer's patches have a high capability of changing their structure in relation to the degree of T lymphocyte recirculation and the venules of these 2 lymphoid organs are closely related entities structurally and functionally. The post-capillary venules of the thymus are different from these vessels structurally and functionally. The existence of only flat endothelium walled venules in the thymus may be related to the fact that the mature T lymphocytes do not recirculate through the thymus after they have left the gland.