Effect of 8-methoxypsoralen plus UVA (PUVA) on lymphocyte transformation and T cells in psoriatic patients

Fräki, J.E.; Eskola, J.; Hopsu-Havu, V.K.

British Journal of Dermatology 100(5): 543-550


ISSN/ISBN: 0007-0963
PMID: 312653
DOI: 10.1111/j.1365-2133.1979.tb05579.x
Accession: 068526014

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The peripheral blood lymphocytes of the psoriatic patients studied initially showed a normal response to phytohemagglutinin (PHA) and to purified protein derivative of tuberculin (PPD) in a microculture using whole blood, but a lower than normal response to a high concentration of concanavalin (Con) A. The initial level of E light (PUVA) did not suppress the lymphocyte responses to PHA, Con A or PPD, rather the responses showed a tendency to be slightly increased. No changes in the mitogen responses of peripheral blood lymphocytes were recorded during or after 12 wk PUVA therapy for psoriasis. The lymphocytes still showed a weaker than normal response to a high concentration of Con A. The percentage of E-rosette-forming T cells in the peripheral blood increased from 51.3% to 62.8% after 12 wk PUVA therapy. The low initial level of E-rosette-forming T cells correlated more closely with the activity than with the extent of the disease. The increase found in the E-rosette-forming cells during PUVA therapy did not correlate with the improvement of the psoriatic lesions. The low response of peripheral blood lymphocytes of psoriatic patients to a high concentration of Con A correlated with the age of the patients but not with the activity or extent of the disease.