Regulatory mechanism of delayed-type hypersensitivity in mice. I. Properties of memory cpells and suppressor cells for delayed-type hypersensitivity against ovalbumin

Kojima, A.; Tamura, S.; Egashira, Y.

Cellular Immunology 45(1): 61-73


ISSN/ISBN: 0008-8749
PMID: 313279
DOI: 10.1016/0008-8749(79)90362-9
Accession: 068526053

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Delayed-type hypersensitivity (DTH) response in mice induced by s.c. injection of alum-absorbed ovalbumin (OA) was accelerated and enhanced by priming s.c. with a low dose of urea-denatured ovalbumin (UD-OA), 2 or more days earlier, whereas it was suppressed by priming s.c. with a higher dose of UD-OA, 0 or more days earlier. The ability in primed mice to accelerate or suppress the DTH response could be transferred antigen specifically into cyclophosphamide (CY)-pretreated recipients or normal recipients by spleen cells from primed mice, but not by the T-cell-depleted spleen cells. The ability of spleen cells to transfer the acceleration or the suppression appeared transiently around 7 or 4 days after priming, though the acceleration or suppression in donor mice persisted for a much longer time. Pretreatment with CY abolished the suppression of DTH response in high dose-primed mice and resulted in the acceleration of DTH response. The activity of DTH-related memory T cells, which accelerate and enhance the response, apparently is inhibited by suppressor T cells for the DTH response.