The requirement for biotin and fatty acids in the cytotoxic T-cell response

Kung, J.T.; Mackenzie, C.G.; Talmage, D.W.

Cellular Immunology 48(1): 100-110

1979


ISSN/ISBN: 0008-8749
PMID: 315827
DOI: 10.1016/0008-8749(79)90103-5
Accession: 068526131

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Abstract
Dialyzed fetal calf serum (FCS) was a poor source of serum supplement for in vitro cytotoxic A-induced spleen cell supernatant, a source of helper factor(s). Fatty acid biosynthesis and the attendant synthesis of structural lipids of appropriate fatty acid composition play a prominent role in the generation of CTL.