EurekaMag
+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Role of Candida albicans in granulomatous tissue reactions. II. In vivo degradation of C. albicans in hepatic macrophages of mice


Role of Candida albicans in granulomatous tissue reactions. II. In vivo degradation of C. albicans in hepatic macrophages of mice



Journal of Infectious Diseases 135(2): 235-242



ISSN/ISBN: 0022-1899

PMID: 320274

DOI: 10.1093/infdis/135.2.235

Hepatic granulomas were induced in mice by injection of blastospores, cell walls, and glucan of Candida albicans. Granulomatous reactions in liver tissue initially multiplied but later decreased. A dose-response relationship was apparent with up to 3 mg of inoculum. Shortly after injection of C. albicans spores, fungal elements appeared in liver macrophages and were detectable in granuloma and Kupffer cells for 20 days. Gram-stain, periodic acid-Schiff (PAS), and immunofluorescence reactions soon vanished, and the organisms could no longer be seen. Glucan of C. albicans, which lacked PAS and immunofluorescence reactivity, proved active in initiation of granulomas. Degradation of phagocytized spores of C. albicans, reductions of cytoplasm, and cell wall deformation and collapse support the premise that loss of PAS and immunofluorescence reactivity was caused by enzymatic breakdown of candida cell wall mannan in macrophages. We conclude that C. albicans can induce granulomatous reactions in mouse liver when the glucan that forms the cell wall matrix in Candida persists in identifiable residues.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 068526202

Download citation: RISBibTeXText

Related references

Role of Candida albicans in granulomatous tissue reactions. I. In vitro degradation of C. albicans and immunospecificity of split products. Journal of Infectious Diseases 135(2): 224-234, 1977

Mice lacking both G-CSF and IL-6 are more susceptible to Candida albicans infection: critical role of neutrophils in defense against Candida albicans. Growth Factors 26(1): 23-34, 2008

Experimental investigation of immunreactivity against Candida albicans. 1. Reaction of rabbits immunized with Candida albicans and challenged with living Candida albicans. Mykosen 14(8): 385-392, 1971

Comparison of the MUREX C albicans, Albicans-Sure, and Bacti Card Candida with the germ tube test for the presumptive identification of Candida albicans. Abstracts of the General Meeting of the American Society for Microbiology 95: 72, 1995

Pathogenesis of Candida albicans infection following antibiotic therapy. III. The effect of antibiotics on the incidence of Candida albicans in the intestinal tract of mice. Journal of Bacteriology 70(4): 440-447, 1955

Quantitative evaluation of tissue invasion by wild type, hyphal and SAP mutants of Candida albicans, and non-albicans Candida species in reconstituted human oral epithelium. Journal of Oral Pathology and Medicine: Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 35(8): 484-491, 2006

Resistance of SCID mice to Candida albicans administered intravenously or colonizing the gut: role of polymorphonuclear leukocytes and macrophages. Journal of Infectious Diseases 167(4): 912-919, 1993

Hyphae and yeast of Candida albicans differentially regulate IL-12 production by human blood monocytes Inhibitory role of Candida albicans germination. Journal of Investigative Dermatology 117(2): 437, 2001

Pulmonary defence mechanism in mice. A comparative role of alveolar macrophages and polymorphonuclear cells against infection with Candida albicans. Journal of Clinical and Laboratory Immunology 19(3): 127-133, 1986

Role of Non-Albicans Candida and Candida Albicans in Oral Squamous Cell Cancer Patients. Journal of Oral and Maxillofacial Surgery: Official Journal of the American Association of Oral and Maxillofacial Surgeons 76(12): 2564-2571, 2018

Characteristics of invasive candidiasis in gamma interferon- and interleukin-4-deficient mice: role of macrophages in host defense against Candida albicans. Infection and Immunity 66(4): 1708-1717, 1998

Role of p H response in Candida albicans virulence : Die p H-Abhngigkeit der Virulenz von Candida albicans. Mycoses 45(S1): 16-21, 2002

Comparison of the MUREX C. albicans, Albicans-Sure, and Bacti Card Candida test kits with the germ tube test for presumptive identification of Candida albicans. Journal of Clinical Microbiology 34(10): 2616-2618, 1996

Rapid identification of Candida albicans and its related species Candida stellatoidea and Candida dubliniensis by a single PCR amplification using primers specific for the repetitive sequence (RPS) of Candida albicans. Journal of Dermatological Science 40(1): 43-50, 2005

Enhanced resistance against systemic Candida albicans infection in mice treated with C. albicans DNA. Fems Immunology and Medical Microbiology 53(2): 231-236, 2008