Suppression of serum LH-RH and LH in rats by an inhibitor of norepinephrine synthesis

Kalra, S.P.

Journal of Reproduction and Fertility 49(2): 371-373


ISSN/ISBN: 0022-4251
PMID: 321776
DOI: 10.1530/jrf.0.0490371
Accession: 068526235

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The inhibition of pituitary LH were not significantly altered following U-14,624 injection. The present results are the only ones known to suggest that the disruption of norepinephrine systems in the hypothalamus leads to impaired release of LH-RH, although LH-RH content in the MBH and the POA did not appear to be affected. Secretory activity of the LH-RH-reducing elements in the preoptic-tuberal pathway is apparently markedly affected by the subnormal levels of brain norepinephrine induced by the catecholamine synthesis inhibitor.