Response of P. vivax and P. falciparum cases to presumptive treatment with chloroquine in some districts of Karnataka

Roy, R.G.; Madesayya, N.M.; Ghosh, R.B.; Sitaraman, N.L.; Ramakrishnan, T.N.; Nair, T.R.; Balasubramaniam, V.

Indian Journal of Medical Research 66(6): 922-928


ISSN/ISBN: 0019-5340
PMID: 346479
Accession: 068526725

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Due to large scale resurgence of malaria in some parts of Karnataka state [India], it has become difficult to administer radical treatment (RT) to all malaria parasite positive cases. Many cases therefore receive only presumptive treatment (PT) with 600 mg base of chloroquine (adult dose). The result that could be expected from this single dose was investigated on 674 Plasmodium vivax and 391 P. falciparum cases which were followed up at an interval of 7-10 days. Persistence of parasites of the respective species was noted in 1.18% and 0.25% P. vivax and P. falciparum cases, respectively, for the entire State but in individual localities P. vivax ranged from 0-4.2%. There was only 1 case of P. falciparum. The purpose of giving presumptive treatment was apparently being served faily well. It was suggested that where radical treatment is not possible, another single dose of chloroquine should be given and the younger age group in particular is likely to derive good benefit from this.