Antiepileptic drug development: I. History and a program for progress

Krall, R.L.; Penry, J.K.; Kupferberg, H.J.; Swinyard, E.A.

Epilepsia 19(4): 393-408


ISSN/ISBN: 0013-9580
PMID: 359324
DOI: 10.1111/j.1528-1157.1978.tb04506.x
Accession: 068526942

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The history of antiepileptic drugs (potassium bromide, phenobarbital, mephobarbital, phenytoin, trimethadione, phenacemide, methsuximide, ethosuximide, mephenytoin, ethotosin, metharbital, primidone, paramethadione, phethenylate, benzchlorpropamide, aminoglutethimide, carbamazepine, clonazepam, diazepam, phensuximide and valporic acid) was reviewed. The approaches to human antiepileptic drug development, i.e., substantiating the need for new therapy, reducing the cost of development and seeking drug characteristics, were the basis for the Antiepileptic Drug Development Program.