Catecholamine-induced changes in plasma glucose, glucagon and insulin in rabbits: effects of somatostatin

Potter, D.E.; Barnett, J.W.; Woodson, L.C.

Hormone and Metabolic Research 10(5): 373-377


ISSN/ISBN: 0018-5043
PMID: 361531
DOI: 10.1055/s-0028-1093394
Accession: 068527011

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The present study was conducted to determine if glucagon release is involved in the hyperglycemic response to epinephrine and isoproterenol in the fasted and fed, unanesthetized rabbit. Epinephrine produced dose-related increases in plasma glucose and glucagon levels in fed and fasted rabbits whereas isoprotereol produced modest hyperglycemia without hyperglucagonemia. Infusion of somatostatin suppressed epinephrine-induced glucagon release and this was correlated with a 50% reduction in the hyperglycemic response. These data suggest that epinephrine-induced glucagon release is the primary reason for the difference in hyperglycemic activity between epinephrine and isoproterenol in the unanesthetized rabbit.