An analysis of B cell memory. I. Interaction of helper and suppressor effects in the in vitro expression of IgM memory

Pilarski, L.M.

Cellular Immunology 40(2): 376-388


ISSN/ISBN: 0008-8749
PMID: 363281
DOI: 10.1016/0008-8749(78)90345-3
Accession: 068527055

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The pfc cells were essential for B cell proliferation even with LPS present in culture. Under appropriate conditions, helper activity could be provided by normal thymus cells. Secondly, activated T cells were required for the maximal conversion of normal thymus cells to helper cells. A 3rd activity, T cell-dependent suppression, was observed at high cell doses. The implications of these results and the need for a comprehensive analysis of in vitro conditions for each individual type of experiment is discussed.