Serum flavin levels and urinary excretion of riboflavin and riboflavin tetrabutyrate--a comparative evaluation

Ramakrishnan, P.; Sheth, U.K.

Indian Journal of Medical Research 66(4): 618-626


ISSN/ISBN: 0019-5340
PMID: 608729
Accession: 068531886

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The suitability of the synthetic fatty acid ester of riboflavin, riboflavin tetrabutyrate (RT) as a substitute for riboflavin in the treatment of riboflacin deficiency was evaluated with reference to absorption, serum flavin levels and urinary flavin excretion. Equivalent doses of riboflavin and RT were orally administered to 10 normal subjects and serum and urine flavin levels were measured fluorimetrically at different time intervals. The flavin levels with RT in comparison to those with riboflavin were maintained at a more constant level and were significantly higher from 8-24 h. The excretion of flavin in urine with RT was less and the rate slower in comparison with riboflavin. These confirm the depot type of action of the synthetic ester of riboflavin.