+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The immediate effects of naftidrofuryl on the human electrocochleogram in Ménière's disorder



The immediate effects of naftidrofuryl on the human electrocochleogram in Ménière's disorder



Journal of Laryngology and Otology 91(8): 679-696



A recognizable electrocochleographic abnormality can be recorded from the ears of patients suffering from Meniere's disorder, i.e., a small distorted CM [summating potential] and an enhanced SP [cochlear microphonic] (relative to the amplitude of the AP [action potential]). These abnormalities can be recorded consistently at intervals of < 1 min; and so they can be used to monitor the effects of pharmacological agents on the human cochlea in Meniere's disorder, avoiding the need for any animal model. Using electrocochleography, it appeared that naftidrofuryl when infused i.v. certainly affected the cochlear potentials in Meniere's disorder. In general the CM increased immediately after infusion, reaching a maximum after about 10 min. The SP component decreased, and this effect was maximal after about 20 min, but lasted for at least 1 h after infusion. Most patients noted an increase in their hearing during this period which could be detected simply using conventional pure tone audiometry. The patients who showed definite changes after the i.v. infusion of naftidrofuryl appeared to have complete remission of vertiginous symptoms on receiving oral naftidrofuryl, but the follow-up period was short. There may have been a considerable placebo effect in performing electrocochleography and taking such interest in each case. Until a properly controlled trial is conducted, it is unwise to make any special claims for the efficacy of naftidrofuryl in Meniere's disorder, but initial results have certainly been very encouraging.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 068537442

Download citation: RISBibTeXText

PMID: 894121

DOI: 10.1017/s002221510008422x


Related references

The immediate effects of naftidrofuryl on the human electrocochleogram in Mnire's disorder. The Journal of Laryngology and Otology 91(8): 679-696, 1977

Short Term Effects of Induced Middle Ear Pressure Changes on the Electrocochleogram in Meniere's Disease. Acta Oto-laryngologica 115(6): 732-737, 1995

Short term effects of induced middle ear pressure changes on the electrocochleogram in Menière's disease. Acta Oto-Laryngologica 115(6): 732-737, 1995

Application of the electrocochleogram in Menière's syndrome. Zhonghua Shen Jing Jing Shen Ke Za Zhi 22(3): 160, 1989

The immediate effects of naftidrofuryl on the human electro cochleogram in menieres disorder preliminary findings. Journal of Laryngology and Otology 91(8): 679-696, 1977

Spectral analysis of electrocochleogram in Menière's disease. Zhonghua Er Bi Yan Hou Ke Za Zhi 24(4): 221, 1989

Long-term follow-up of electrocochleogram in Ménière's disease. ORL 53(3): 131-136, 1991

The long term follow up of electrocochleogram ecochg in meniere's disease. Practica Otologica Kyoto (Suppl. 48): 1-8, 1991

Research on the auditory brainstem response and electrocochleogram in meniere's syndrome patients. Baiqiuen Yike Daxue Xuebao 12(2): 114-117, 1986

Use of ICF in assessing the effects of Meniere's disorder on life. Annals of Otology Rhinology and Laryngology 119(9): 583-589, 2010

The effects of Ménière's disorder on the patient's significant others. International Journal of Audiology 51(12): 858-863, 2012

Effects of naftidrofuryl on hypoxia-induced activation and mortality of human endothelial cells. Journal of Pharmacology and Experimental Therapeutics 267(2): 904-911, 1993

Effects of buflomedil and naftidrofuryl on the human cochlear microcirculation measured by laser-Doppler. Revue de Laryngologie - Otologie - Rhinologie 116(1): 69-72, 1995

Naftidrofuryl in chronic arterial disease. Results of a six month controlled multicenter study using Naftidrofuryl tablets 200 mg. Angiology 37(3 Pt 1): 160-167, 1986

Naftidrofuryl in chronic arterial disease results of a six month controlled multicenter study using 200 milligram naftidrofuryl tablets. Angiology 37(3 Part 1): 160-167, 1986