+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Reaginic and homocytotropic IgG antibody response of Mastomys natalensis in experimental infections of filarial parasites (Litomosoides carinii, Dipetalonema viteae, Brugia malayi, B. pahangi)



Reaginic and homocytotropic IgG antibody response of Mastomys natalensis in experimental infections of filarial parasites (Litomosoides carinii, Dipetalonema viteae, Brugia malayi, B. pahangi)



Parasitology Research 73(3): 271-280



Reaginic and homocytotropic IgG antibodies in sera using passive cutaneous anaphylaxis (PCA) test and antigen from Litomosoides carinii were followed in Mastomys natalensis, infected with L. carinii, Dipetalonema viteae, Brugia malayi or B. pahangi. Groups of animals with infections of various ages so as to cover a total infection period of up to 300 to 420 days post-infection (p.i.), depending on the species of parasites, were bled at 1- to 3-week intervals over periods of 50-112 days. In addition, intradermal tests were performed on animals infected with L. carinii to detect immediate type hypersensitivity. Reaginic antibodies were usually first detected in the 3rd week after infection. Thereafter, a marked increase of PCA titres was observed in the 4th week p.i. leading to maximum titres 4 weeks after infection with D. viteae and B. pahangi and 6 weeks after B. malayi infection. Mean maximum titres were between 1:40 and 1:160. Following the peak response, titres decreased markedly until the beginning of patency in infections with D. viteae, B. malayi and B. pahangi whereas a constant course was observed at this time in animals infected with L. carinii. A further rise in PCA titres occurred in all infections around the beginning of patency, resulting in maximum reagin levels in L. carinii infections (mean titre 1:80) and moderate titres in the other infections. During early patency there was an inverse relationship between microfilaraemia density and levels of reaginic antibodies. However, in the phase of decreasing parasitaemia in L. carinii infected animals, microfilariae counts and PCA titres were directly correlated. Homocytotropic IgG antibodies showed relatively constant PCA titres of about 1:20 in L. carinii infected Mastomys throughout the observation period. In D. viteae infections they were demonstrated at 30 days p.i., reaching titres of about 1:40. B. malayi infected animals showed a maximum titre of 1:40 40 days p.i.. Thereafter, titres decreased continuously and homocytotropic IgG antibodies were absent at 110 days p.i.. High titres were observed at day 150 but thereafter sera were negative. B. pahangi infected animals showed moderate titres (1:5) 35 days p.i.. Thereafter, antibodies were found at low titres until 115 days p.i.. Intradermal reactions in L. carinii infected animals generally increased in size from 30-60 but decreased when microfilariae appeared in the blood.(ABSTRACT TRUNCATED AT 400 WORDS)

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 068584871

Download citation: RISBibTeXText

PMID: 3588585

DOI: 10.1007/bf00578517


Related references

Reaginic and homocytotropic igg antibody response of mastomys natalensis in experimental infections of filarial parasites litomosoides carinii dipetalonema viteae brugia malayi brugia pahangi. Parasitology Research 73(3): 271-280, 1987

19s and 7s antibody response of mastomys natalensis in experimental filarial litomosoides carinii acanthocheilonema viteae brugia malayi brugia pahangi infections. Journal of Veterinary Medicine Series B 36(5): 374-384, 1989

19s and 7s antibody response of Mastomys natalensis in experimental filarial (Litomosoides carinii, Acanthocheilonema viteae, Brugia malayi, B. pahangi) infections. Journal of Veterinary Medicine Series B: 365: 374-384, 1989

Studies on the humoral immune response of Mastomys natalensis in the courses of experimental filarial infection (Litomosoides carinii, Dipetalonema viteae, Brugia malayi and Brugia pahangi). 1985

Different suitability of 3 filarial antigens (Litomosoides carinii, Dipetalonema viteae, Dirofilaria immitis) to act as allergens in the Passive Cutaneous Anaphylaxis Test and to serve as antigens in an ELISA in the course of experimental filarial infections (L. carinii, D. viteae, Brugia malayi, B. pahangi) of Mastomys natalensis. Acta Tropica 41(1): 51-60, 1984

Time courses of antibody levels in Mastomys natalensis after infections with Litomosoides carinii, Dipetalonema viteae, Brugia malayi or B. pahangi, Determined by ELISA. Zeitschrift für Parasitenkunde 69(5): 681-692, 1983

Time courses of antibody levels in mastomys natalensis after infections with litomosoides carinii dipetalonema viteae brugia malayi or brugia pahangi determined by elisa enzyme linked immuno sorbent assay. Zeitschrift fuer Parasitenkunde 69(5): 681-692, 1983

Antifilarial activities of benzazole derivatives. 1. Macrofilaricidal effects against Litomosoides carinii, Dipetalonema viteae, Brugia malayi, and B. pahangi in Mastomys natalensis. Tropical Medicine and Parasitology 39(1): 14-18, 1988

Altered immune response (humoral and delayed-type hypersensitivity reactions) to sheep red blood cells in the course of experimental filarial infections (Litomosoides carinii, Brugia malayi, Acanthocheilonema viteae) of Mastomys natalensis. Parasitology Research 75(5): 401-411, 1989

Comparative investigations in litomosoides carinii dipetalonema viteae brugia malayi subperiodic and brugia pahangi infection of the strain gra giessen and the new albino strain albino giessen of mastomys natalensis. Zentralblatt fuer Bakteriologie Mikrobiologie und Hygiene Series A 258(2-3): 403, 1984

Detection of circulating and urinary antigens in Mastomys natalensis experimentally infected with Brugia malayi, Brugia pahangi, or Litomosoides carinii. Parasitology Research 74(2): 191-195, 1987

Ocular filarial infection in Mastomys natalensis with Litomosoides carinii and Brugia pahangi. Indian Journal of Parasitology 7(1): 57-60, 1983

Experimental chemotherapy of filariasis: comparative evaluation of the efficacy of filaricidal compounds in Mastomys coucha infected with Litomosoides carinii, Acanthocheilonema viteae, Brugia malayi and B. pahangi. Acta Tropica 52(4): 221-266, 1993

Effect of ivermectin in Dipetalonema viteae and Litomosoides carinii infections of Mastomys natalensis. Tropical Medicine and Parasitology 38(2): 117-122, 1987

Antifilarial activities of benzazole derivatives. 2. Microfilaricidal effects against Litomosoides carinii, Acanthocheilonema. vitae, Brugia malayi and B. pahangi in Mastomys natalensis. Tropical Medicine and Parasitology 39(4): 284-290, 1988