Section 69
Chapter 68,605

The fate of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) following oral administration to man

Gehring, P.J.; Kramer, C.G.; Schwetz, B.A.; Rose, J.Q.; Rowe, V.K.

Toxicology and Applied Pharmacology 26(3): 352-361


ISSN/ISBN: 0041-008X
PMID: 4588304
DOI: 10.1016/0041-008x(73)90271-8
Accession: 068604496

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Five human male volunteers ingested a single dose of 5 mg 2,4,5-T/kg without detectable clinical effects. The clearances of 2,4,5-T from the plasma as well as its excretion from the body occurred via apparent first-order rate processes with half-lives of approximately 23h. All the 2,4,5-T was absorbed into the body and excreted unchanged in the urine. In the body 65% of the 2,4,5-T resided in the plasma where 97.7% was bound reversibly to protein. The volume of distribution was 0.079 litres/kg. It was calculated that plasma concns. of 2,4,5-T in individuals ingesting the compound daily would reach a plateau after 3 days. If the daily dose absorbed into the body is 0.1 mg/kg the concn. may be expected to range from 1.3 to 2.2 mu g/ml after the plateau is attained. From summary.

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